There are many science fiction films, TV programs, and Video games, that feature Reptilian Creatures. Here in my opinion are three of the best.

Enemy Mine (1985): Directed by Wolfgang Petersen. Written by Edward
Khmarat and Barry Longyear. Enemy Mine is about a war between Humans
and The Draco. A human (Dennis Quaid) and a Draco get shot down on a
barren planet. And have to band together to survive. The Tagline to the
film sums it up brilliantly. �Enemies because they were taught to be. Allies
because they had to be. Brothers because they dared to be.�

The Arrival 1 (1996): Written and directed by David N.Twohy. A radio
astronomer (Charlie Sheen) picks up a radio signal not from space, but from
earth. The Signal leads him to Mexico where he discovers a huge
underground alien base. Where aliens are speeding up the global warming
process.

Farscape TV series (1999-2003): Created by Rockne S. O�Bannon. Astronaut
John Crichton (Ben Browder) ends up being hurled into deep space. And
taken on board Moya, a living breathing spaceship. There he makes friends
with many Different alien races. He is hunted by the Scarrans. To me the
Scarrans are a Perfect Visual representation of how the real Reptilians look.